Who’s Affected by Depression?

A mood disorder that affects more than 264 million people worldwide, depression differs from normal mood fluctuations and emotional responses in that its characteristic feelings of sadness and loss of interest in previously-enjoyed activities are persistent, last for two weeks or longer, and can drastically impact a person’s ability to function in various contexts including at work, at school, and with family and friends.

Depression, also known as major depressive disorder or clinical depression, can affect anyone, regardless of their age, the country or state they live in, their home life, their employment and financial status, or social position. Factors that may play a role in its development include biochemistry, genetics, personality, and environmental factors. [1] Because no group of people in the world is exempt from the experience of depression, the symptoms vary widely. In adults, they most commonly include:

• Feelings of sadness, tearfulness, emptiness, or hopelessness
• Angry outbursts, irritability, or frustration, even over small matters
• Loss of interest or pleasure in most or all normal activities, such as sex, hobbies, or sports
• Sleep disturbances, including insomnia or sleeping too much
• Tiredness and lack of energy, so even small tasks take extra effort
• Reduced appetite and weight loss or increased cravings for food and weight gain
• Anxiety, agitation, or restlessness; increase in purposeless physical activity
• Slowed thinking, speech, or body movements
• Feelings of worthlessness or guilt, fixating on past failures or self-blame
• Trouble thinking, concentrating, making decisions, and remembering things
• Frequent or recurrent thoughts of death, suicidal thoughts, suicide attempts, or suicide
• Unexplained physical problems, such as back pain or headaches
• General misery or unhappiness with no discernible cause [1, 2]

Depression may present in younger children as “sadness, irritability, clinginess, worry, aches and pains, refusing to go to school, or being underweight,” and in teenagers as “sadness, irritability, feeling negative and worthless, anger, poor performance or attendance at school, feeling misunderstood and extremely sensitive, using recreational drugs or alcohol, eating or sleeping too much, self-harm, loss of interest in normal activities, and avoidance of social interaction.” [2]

Some people may experience depression as a single episode, while others may have several episodes throughout their lifetimes. While it mimics some features of grief, depression is generally characterized by constant sadness usually accompanied by feelings of self-loathing whereas grief is distinguished as waves of painful feelings that don’t lower one’s self-esteem. Acute grief may lead to depression, increasing the severity and length of the episode and escalating the necessity of appropriate treatment.

What Treatment Options are Available? 

According to the WHO, depression is the leading cause of disability worldwide. [3] Often classified as a disease itself, depression can also contribute to the development of other conditions such as tuberculosis and cardiovascular disease. Estimates suggest that one in 15 adults will be affected by depression each year, and women are more likely to be affected than men are. [1] A variety of treatment options exist, including psychological intervention like behavioral activation, cognitive behavioral therapy, and interpersonal psychotherapy; pharmaceutical antidepressants like selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs); self-help and coping strategies; and, in severe cases, electroconvulsive therapy (ECT).

Treatment generally provides some degree of relief, with 80 to 90% of patients who receive treatment for depression eventually exhibiting positive responses. However, these options are not available to sufferers of depression in low- and middle-income countries. The WHO estimates that 76-85% of the people affected by depression in such countries cannot get access to needed treatment. [4]

How Do SSRIs Work?

Pharmaceutical treatment options are often effective for moderate to severe cases of depression after several weeks of consistent intake at the correct dosage. The most-often prescribed pharmaceuticals are SSRIs, which are designed to increase the amount of serotonin in the spaces between neurons. They bind to the transport mechanisms (called SERT) that carry serotonin back to pre-synaptic cells for “recycling.” However, scientists and researchers have never found conclusive evidence that depression is caused by a deficiency in serotonin. As Dr. Gary Wenk notes, “Depletion of serotonin can cause depression; however, this is not proof that the cause of depression is actually due to the depletion of serotonin or reduced activity of serotonin neurons.” [6] In fact, recent research suggests that reduced synaptogenesis (the growth of new synapses) and neurogenesis (the generation of new neurons) activity may play a significant role in causing depression symptoms, and serotonin deficiency may point to this larger problem. [5] 

Though not specifically designed for this function, SSRIs are thought to improve synaptogenesis and neurogenesis by activating genes that produce an integrin protein called ITGB3. SSRIs bind to SERT, slowing its activity. This triggers the production of more ITGB3, which in turn stimulates synaptogenesis and neurogenesis activity. Several studies have been conducted to support these theories, and the findings may lead to the development of a drug that more directly increases the levels of synapse growth and neuron development.

Perhaps because SSRIs don’t actually target the true cause of depression, they don’t usually benefit patients with mild cases. For those who do experience positive results, it generally takes between four and six weeks for symptoms to begin to improve even though serotonin levels increase almost immediately after a patient starts following an SSRI protocol. It may take months to experience full efficacy. In that time span, the brain undergoes a number of biochemical changes. Not only does the number of serotonin receptors increase, but “dopamine receptor signaling changes dramatically in some regions, norepinephrine release increases in other brain regions, inflammatory protein levels—particularly tumor necrosis factor-alpha—are reduced, BDNF (brain-derived neurotrophic factor) levels increase, neurogenesis increases in the hippocampus, and so on.” [6]

What Are The Side Effects?

In addition to their ineffectiveness for mild cases of depression and the delay in symptom reduction, SSRIs carry an extensive list of potential side effects that may occur during the course of treatment and/or when treatment stops. Taking SSRIs may cause “nausea, increased appetite and weight gain, loss of sexual desire and other sexual problems, fatigue and drowsiness, insomnia, dry mouth, blurred vision, constipation, dizziness, agitation, irritability, and anxiety.” [7]  

While not a common occurrence, enough cases of violent or self-destructive actions have been linked to SSRIs that the FDA initiated a Black Box warning in 2004. It is the FDA’s “strongest available measure short of withdrawing a drug from the market” and mandates that every antidepressant package contain an insert stating that “children, adolescents, and young adults with major depression or other psychiatric disorder who take antidepressants may be at increased risk of suicidal thoughts and behavior, especially during the first month of treatment” or when their doctor changes the dose. [7, 8]

SSRIs can also cause serotonin syndrome when taken in combination with other serotonin level-raising medications. Symptoms may include anxiety, agitation, racing heart, sweating, high fever, tremors, lack of coordination, high blood pressure, confusion, and sometimes delirium. [8, 9] Stopping treatment without following doctors’ instructions can produce withdrawal-like effects, though SSRIs are not addictive. These can present as dizziness, loss of coordination, fatigue, tingling, burning, blurred vision, insomnia, vivid dreams, nausea or diarrhea, flu-like symptoms, irritability, anxiety, and crying spells. [8] These side effects exist because SSRIs contain synthetic substances that alter brain chemistry and often cause adverse reactions as the body detects unnatural intruders.

Are There Natural Alternatives?

So much remains unknown about both the root cause of depression and the true function of SSRIs. This can create reasonable distrust in conventional medicine and chemical cures. While they cannot be prescribed as effective alternatives to antidepressant drugs, natural mood boosters like U.S. Doctors’ Clinical Serezec Plus may positively impact mood and encourage brain health through the use of vitamins, minerals, and amino acids.*

U.S. Doctors’ Clinical Serezec Plus contains a proprietary blend of SAMe, a natural hormone-regulating compound, and DL-Methionine and L-Tyrosine, two amino acids essential for balanced brain function and hormone levels, in an enterically coated tablet that delivers nutrients directly to the small intestine for maximum absorption and mood elevation.* It also includes a B vitamin complex and minerals calcium and magnesium to support the nervous system and promote heart health.*

The Big Three: SAMe, Methionine, and Tyrosine

Discovered in the early 1950s, S-adenosyl-L-methionine, or SAMe, regulates vital cellular functions, plays a role in genetic expression, helps to maintain immune system health, and participates in the metabolism of amino acids. At healthy levels, SAMe balances hormones and keeps cell membranes healthy. Low levels may negatively impact mood and contribute to the development of depression and liver disease.

Studies conducted on SAMe have turned up evidence that suggests it possesses antidepressant effects related to its role in neurotransmitter synthesis. Participants in these studies who received SAMe treatment demonstrated an “increased rate of serotonin turnover, inhibition of norepinephrine reuptake, and beneficial synergistic effects on dopamine” as well as anti-inflammatory effects and changes in neuronal membrane activity. [10] These studies noted positive effects fairly quickly, with key indicators shifting in as little as a week, and also suggested that SAMe supplementation might augment the effects of SSRIs. They did not witness any clinically significant harmful interactions with prescription medications, and found few noteworthy side effects—especially when compared to pharmaceutical antidepressants.

DL-Methionine, an amino acid, is rich in sulfur and involved in detoxification and anti-aging processes throughout the body. It has several unique characteristics, including the ability to convert into sulfur-containing molecules that protect tissues, modify DNA, help build new proteins to replace disintegrating ones, and aid in the production of cysteine, another amino acid that enables the production of proteins, “master antioxidant” glutathione, and taurine. [11]

Research suggests that increasing intake of methionine during pregnancy can reduce the risk of neural tube birth defects, and methionine may also help to combat symptoms of Parkinson’s disease like tremors, lack of motor control, and rigidity. Abnormally large doses may cause dizziness, sleepiness, and blood pressure changes, but no major side effects have been reported. [11]

L-Tyrosine is an amino acid produced from phenylalanine. It is involved in the formation of the neurotransmitters dopamine, adrenaline, and norepinephrine, which enable nerve cell communication and help regulate mood; thyroid hormones that regulate metabolism; and melanin, which gives skin, hair, and eyes its color. Studies have demonstrated a link between tyrosine supplementation and improved cognitive flexibility, or the ability to switch quickly between tasks or thoughts. It may also work to counter sleep deprivation, reverse mental decline, and improve cognitive function in high-stress situations. [12]

Because it may increase levels of neurotransmitters thought to play a role in mitigating depression symptoms, tyrosine could benefit depressed individuals who have tested deficient in dopamine, adrenaline, or noradrenaline. Supplementation may also help boost memory and improve performance in mentally demanding circumstances. [12] Tyrosine is generally considered safe, even in high doses, though it may interact with thyroid medications, the Parkinson’s medication L-dopa, and monoamine oxidase inhibitors (powerful antidepressants commonly referred to as MAOIs). 

B Vitamins: A Colony of Benefits 

U.S. Doctors’ Clinical Serezec Plus contains vitamin B1, B2, B3, B5, B6, and B12 to provide multifaceted support for a variety of systems and functions.* Thiamine, or vitamin B1, helps to convert nutrients into usable energy for metabolism regulation. Riboflavin (B2) also plays a role in the energy conversion process, as well as acting as an antioxidant. Niacin (B3) is involved in cellular signaling and the production and repair of DNA. Pantothenic acid (B5) works with B1 and B2 to aid metabolism processes, and participates in the production of hormones and cholesterol. Vitamin B6, or pyridoxine, enables the metabolism of amino acids and the creation of red blood cells and neurotransmitters. Finally, cobalamin (B12) is essential for proper neurological function and works with B3 to produce DNA and B6 to create red blood cells. [13]

Studies conducted on the benefits of vitamin B complexes have suggested potential for mood boosting and the reduction of fatigue. They may also enhance cognitive performance and improve depression and anxiety symptoms. One study found significant improvements in adults with depression after taking a B-complex vitamin for just 60 days. Another found that a vitamin containing vitamins B12, B6, and folic acid “led to a more enhanced and sustained antidepressant response over one year, compared to a placebo.” [13] Because B vitamins are water soluble, they cannot be stored in the body and overconsumption is therefore virtually impossible.

Calcium and Magnesium: Mighty Minerals

Known as the primary building block of bones, calcium also contributes to heart, muscle, and nerve function. It may also help to regulate blood pressure and guard the body against cancer and diabetes. As part of a negative feedback loop with parathyroid hormone (PTH), calcium monitors the regularity of cardiac contractions and prevents the kind of bone degradation that can lead to osteoporosis and increase the risk of fractures. [14]

Magnesium, a mineral found in every cell in the body, is involved in more than 600 different reactions that contribute to “energy creation, protein formation, gene maintenance, muscle movements, and nervous system regulation.” [15] It also plays a vital role in maintaining healthy brain function and an even-keeled mood by enabling processes in the psychoneuroendocrine system, moderating the hypothalamic pituitary adrenal (HPA) axis, and blocking certain receptors to prevent stress and feelings of anxiety. [15] Despite the essential nature of magnesium, more than 60% of American adults do not meet the dietary intake recommendations. Low levels may increase the risk of depression, as well as other neurological conditions like anxiety, migraines, chronic pain, epilepsy, Alzheimer’s, Parkinson’s, and stroke. [16]

Let Serezec Plus Lift Your Spirits, Naturally

Paired with a healthy diet, regular exercise, and a positive environment, U.S. Doctors’ Clinical Serezec Plus can offer continual support for proper brain and thyroid function, normal hormone levels, restful sleep, efficient metabolism, energy production, and stable blood sugar levels—without negative residual effects.* It’s formulated to nourish your body and help you reach your health and vitality goals, rigorously tested and reviewed for quality and efficacy, and manufactured in a state-licensed and FDA-registered facility. Backed by the Advisory Board of Doctors, an expert panel of physicians and health practitioners, Serezec Plus is made with premium-sourced, natural ingredients chosen for maximum purity and effectiveness.*

While natural supplements should not be substituted for doctor-prescribed pharmaceuticals, research shows promise for compounds like SAMe that may help to accelerate the response time and enhance the positive effects of certain SSRIs. As scientists and researchers continue to explore depression and its causes in order to treat it more effectively, it may become increasingly apparent that natural substances can play a significant role in the restoration of brain health and hormone balance—in a way that supports holistic wellness and causes no undesirable side effects.

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*These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

SOURCES

1. https://www.psychiatry.org/patients-families/depression/what-is-depression
2. https://www.mayoclinic.org/diseases-conditions/depression/symptoms-causes/syc-20356007
3. https://www.who.int/news-room/fact-sheets/detail/depression
4. https://www.who.int/health-topics/depression#tab=tab_1
5. https://www.scientificamerican.com/article/unraveling-the-mystery-of-ssris-depression/
6. https://www.psychologytoday.com/us/blog/your-brain-food/202001/when-ssris-fail-treat-depression
7. https://www.webmd.com/depression/features/coping-with-side-effects-of-depression-treatments
8. https://www.health.harvard.edu/mind-and-mood/what-are-the-real-risks-of-antidepressants
9. https://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825
10. https://www.psychologytoday.com/us/blog/integrative-mental-health-care/201811/s-adenosyl-methionine-same-depressed-mood
11. https://www.healthline.com/nutrition/methionine
12. https://www.healthline.com/nutrition/tyrosine
13. https://www.healthline.com/nutrition/vitamin-b-complex
14. https://www.ncbi.nlm.nih.gov/books/NBK499940/
15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024559/
16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163803/